Two years have passed since we left Daniele and the ship of madmen. Many things have changed: Daniele and Nina have become the parents of little Maria and shortly after her birth they separated. We find them fighting for custody of the little girl with the support of their respective, very different families. Daniele, after the intense experience he had during the CHT week, has chosen to become a nurse and, thanks to the intervention of Dr. Cimaroli, he is about to enter as an intern in the hospital where he was admitted. He has five weeks to demonstrate to the judge that this can become a stable job, establishing himself as a reliable parent. In this new role, Daniele gets to know the new patients in the dormitory, who force him to reflect on his excessive empathy towards the pain of others, and who risk derailing him again.
该剧以主要讲述了芝加哥51号消防站应急救援队的故事。这一群英勇的消费队员们包括：副队长Kelly（泰勒·金尼 Taylor Kinney 饰）、队长Walter（伊默恩·沃克 Eamonn Walker 饰）、急救员Gabriella（莫妮卡·雷蒙德 Monica Raymund 饰），对自己的工作十分忠诚、资深消防员Christopher（David Eigenberg 饰）、玩命消防员Matthew（杰西·斯宾塞 Jesse Spencer 饰）、准消防员Peter（Charlie Barnett 饰）等。这群勇敢无惧的男女却义无反顾地冲进最危险的地方，每天都要和死神打交道，要在最紧张的时候做出最重要选择，每天都要面对自尊与自负的考验，工作的责任和压力给他们的性格带来了巨大影响......
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